Vaginal injections of non-crosslinked hyaluronic acid for the relief of vaginal dryness symptoms. A case series. Katarzyna Kopacz-Petranyuk, Andriy Petranyuk, Izabela Karamon, Adrian Karamon
ABSTRACT
Introduction: Vaginal dryness and trophic disorders are a common, underreported problem that decreases quality of life. Standard treatments, such as lubricants, moisturizing products, or hormone therapies, do not always produce the desired results or may be contraindicated. Aim: This study aimed to present the results of a pilot clinical observation regarding intravaginal injections of high-molecularweight non-crosslinked hyaluronic acid in women with severe symptoms of vaginal mucosal and vestibular dryness. Materials and methods: Five women with severe symptoms of dryness, itching, burning, and pain during intercourse received a single submucosal injection of non-crosslinked hyaluronic acid (1.6% or 2.2%). The results were evaluated after four weeks. The analysis included self-assessment, medical evaluation of trophic condition, peri-procedural sensations on an 11-point numerical intensity scale (0-10), and treatment safety. Results: A rapid, clinically significant improvement was observed: the mean self-assessment of lubrication increased from 4.2 to 8.8/10, and itching, burning, and pain during intercourse resolved completely after just one week. A gynecological examination revealed normalization of tissue condition in all areas. Conclusions: The results are consistent with the mechanism of action of non-crosslinked hyaluronic acid and suggest a potential minimally invasive alternative for women who cannot undergo or do not accept hormonal therapy.
Keywords: non-crosslinked hyaluronic acid, vaginal injection, vaginal dryness, vaginal atrophy, dyspareunia, off-label.